ADVFN US – Market Content Editor

Ionis Pharmaceuticals, Inc. (NASDAQ:IONS) jumped 22% on Tuesday after unveiling highly positive topline results from its pivotal Phase 3 CORE and CORE2 trials evaluating olezarsen in patients with severe hypertriglyceridemia (sHTG). The therapy not only lowered fasting triglyceride levels by as much as 72% versus placebo, but also achieved an 85% reduction in acute pancreatitis…

U.S. markets are poised for a weak start Tuesday, with futures pointing lower as investors digest a fresh wave of tariff-related uncertainty. The pressure comes after the U.S. Court of Appeals for the Federal Circuit declared that the bulk of tariffs imposed under former President Donald Trump were unlawful. In a 7-4 decision, the court…

The recent summer rally in U.S. equities, fueled by strong corporate profits, falling Treasury yields, and moderate oil prices, is set for critical scrutiny in the coming weeks, according to Raymond James. In a research note, the firm emphasized that “this rally is built on low oil prices, declining Treasury yields, and steady labor market.”…

U.S. homebuilding shares may attract renewed focus on Tuesday after Treasury Secretary Scott Bessent revealed that the Trump administration is exploring the possibility of declaring a national housing emergency this fall. “We may declare a national housing emergency in the fall,” Bessent told the Washington Examiner, adding that the White House is evaluating ways to…

Amazon (NASDAQ:AMZN) saw its shares slip 1.2% in premarket trading Tuesday, following a Reuters report indicating that U.S. sign-ups for its Prime subscription service slowed during this year’s expanded Prime Day event. Reuters reported that Amazon added 5.4 million new U.S. Prime members across the three weeks leading up to the sale and the four-day…

PepsiCo (NASDAQ:PEP) shares rose 4% after a Wall Street Journal report revealed that activist investor Elliott Investment Management has taken a roughly $4 billion stake in the snack and beverage giant. The report indicated that Elliott aims to push for strategic changes at PepsiCo to lift its underperforming share price. The fund now ranks among…

Cytokinetics (NASDAQ:CYTK) shares jumped 31% after the company released positive results from its MAPLE-HCM trial, which compared its experimental heart medication aficamten with the standard beta blocker metoprolol for treating obstructive hypertrophic cardiomyopathy (oHCM). The late-stage trial showed that aficamten led to improvements in cardiac structure and function versus metoprolol. The results were published in…

Signet Jewelers Limited (NYSE:SIG), the world’s largest diamond jewelry retailer, saw its shares climb 5% in premarket trading on Tuesday following stronger-than-expected second-quarter fiscal 2026 results and an upward revision to its full-year outlook. The company posted adjusted earnings per share of $1.61, comfortably exceeding the analyst consensus of $1.24. Revenue totaled $1.54 billion, surpassing…

Air Lease Corporation (NYSE:AL) shares climbed 5.5% following news that the aircraft leasing company has agreed to be acquired in a transaction valued at roughly $7.4 billion, or $28.2 billion when accounting for debt. According to the terms, holders of Air Lease Class A common stock will receive $65.00 per share in cash, equating to…

Kraft Heinz (NASDAQ:KHC) revealed on Tuesday plans to divide into two publicly traded companies—one focused on sauces and the other on grocery products—in a bid to jumpstart growth following several years of sluggish performance. Shares in the company inched higher during premarket trading but are still down roughly 21% over the past 12 months and…